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Directions for use: On the perfectly clean skin apply TRANACIX Cream twice a day, in the morning and at night, on the considered areas. Slightly massage in order to make its absorption easier. Once perfectly absorbed, make up is possible. Indications: Tranexamic Acid is known as an oral medicine for treating melasma. Its rare but severe side effects when taken orally, such as pulmonary embolism, deep-vein thrombosis, myocardial or cerebrovascular infarction, make risky its systemic use in dermatology. Properties: Plasmin, a kind of protease in the blood serum,functions to enhance the intracellular release of arachidonic acid, a precursor of prostanoid, and also to elevate alpha-melanocyte stimulating hormone processed from pro-opiomelanocortin. Both arachidonic acid and alpha-melanocyte stimulating hormone can activate melanin synthesis by melanocytes. Therefore, the anti-plasmin activity of tranexamic acid is thought to play a role in its topical effectiveness for treating melasma
